NFL Week 10 Predictions & Best Bets

Week 10 is here. The Giants host the Commanders on Thursday night, the Patriots and Lions head to Munich, the Vikings and Bills are on short weeks after Monday night, and Sunday night gives us Steelers-Bengals, an absolute heavyweight clash in the AFC North.

Let's get into it.

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THURSDAY NIGHT

WASHINGTON COMMANDERS @ NEW YORK GIANTS

Thursday, November 12 | 5:15 PM PT | Prime Video

Line: Giants -2.5 | O/U: 41.5

Weather: 51°F at MetLife Stadium

Washington's offense looked stagnant last week, falling to the Rams 20-13. Meanwhile, the Giants grinded out a tough divisional win against the Eagles, 19-11.

New York's defense is playing inspired football right now, especially rookie sensation Arvell Reese. Washington's defense has seemed to improve from week to week behind the development of Sonny Styles, but this will be a tough test on the road on a short week.

It will be interesting to see if JJ McCarthy can play. Either way, I expect the G-men to stick with what's been working: run the ball and play the field position game with their special teams and defense. The Commanders are pretty banged up on the offensive side of the ball, and I expect the Giants to exploit those injuries.

PREDICTION: GIANTS 27, COMMANDERS 17

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SUNDAY MORNING IN MUNICH

NEW ENGLAND PATRIOTS vs. DETROIT LIONS

Sunday, November 15 | 6:30 AM PT | FOX

Line: Lions -2.5 | O/U: 51.5

Weather: 47°F at Allianz Arena, Munich

The Patriots defense completely collapsed last week, giving up 45 points in a blowout loss to the Packers. I was not expecting Christian Gonzalez to get torched the way he did. The Lions, on the other hand, leaned on their rushing attack to grind out a 19-9 win over Miami.

Detroit's offense is always dangerous, and New England's defense looks vulnerable. Jameson Williams and Amon-Ra St. Brown provide a dangerous 1-2 punch that is more than capable of putting up huge numbers against New England.

Oh, and Amon-Ra actually speaks German, as his mom is a German immigrant. I expect him to have a huge day.

PREDICTION: LIONS 31, PATRIOTS 24

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SUNDAY EARLY WINDOW

KANSAS CITY CHIEFS @ ATLANTA FALCONS

Sunday, November 15 | 10:00 AM PT | CBS

Line: Chiefs -3.5 | O/U: 45.5

Weather: Dome

The Chiefs offense was clicking on all cylinders last week, dismantling the Jets 35-12. Kenneth Walker III bounced back in a huge way, scoring 3 total TDs and eclipsing 100 yards on the ground. Patrick Mahomes did take a huge hit, though, so that will be something to keep an eye on heading into Sunday.

In Madrid, the Falcons struggled to keep pace with the Bengals, taking a 34-17 loss. As I write this, the Falcons just traded away safety Jessie Bates.

Even if Justin Fields starts for the Chiefs, I like them to handle the Falcons fairly easily.

PREDICTION: CHIEFS 24, FALCONS 16

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HOUSTON TEXANS @ CLEVELAND BROWNS

Sunday, November 15 | 10:00 AM PT | FOX

Line: Texans -4.5 | O/U: 39.5

Weather: 47°F at Huntington Bank Field

The Texans exploded offensively last week, crushing the winless Chargers 44-22. It was nice to see Tank Dell make his mark coming back from a gruesome injury that had sidelined him since 2024, as he hauled in 4 catches for 105 yards and a TD.

In New Orleans, the Browns suffered a heartbreaking 23-22 overtime loss to the Saints.

Deshaun Watson is expected to play this game for Cleveland, and I know he would love nothing more than to beat his former team. Watson and Cleveland have faced the Texans once before, beating them 27-14 in 2022. The crowd will be behind Watson in this one, and I expect Deshaun to ball out.

Give me the Brownies in an upset.

PREDICTION: BROWNS 24, TEXANS 20

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MINNESOTA VIKINGS @ GREEN BAY PACKERS

Sunday, November 15 | 10:00 AM PT | FOX

Line: Packers -3.5 | O/U: 42.5

Weather: 48°F at Lambeau Field

The Vikings enter this on a short week following their Monday night clash with Buffalo. Green Bay looked unstoppable last week, dropping 45 points on the Patriots. With Minnesota operating on less rest and the Packers finding their offensive groove at Lambeau, Green Bay has the edge.

In their Week 1 matchup, the Packers had the lead in the 4th quarter and went for it instead of taking the points. That decision was part of a brutal 2nd half that cost them the game, as the Vikings scored 29 unanswered points.

Both of these teams know each other well, and I expect the Packers to have learned their lesson. Give me the Pack to get revenge at home.

PREDICTION: PACKERS 26, VIKINGS 16

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JACKSONVILLE JAGUARS @ TENNESSEE TITANS

Sunday, November 15 | 10:00 AM PT | FOX

Line: Jaguars -10.5 | O/U: 46.5

Weather: 54°F at Nissan Stadium

Jacksonville made a massive statement last week, blowing out the Ravens 33-10 on the road. The Titans are in a complete freefall at 1-7.

Double-digit road favorites are always risky, but the talent gap here is enormous. Oh, and Jacksonville just traded for Jessie Bates to make that defense even more potent.

PREDICTION: JAGUARS 30, TITANS 13

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MIAMI DOLPHINS @ INDIANAPOLIS COLTS

Sunday, November 15 | 10:00 AM PT | CBS

Line: Colts -3.5 | O/U: 38.5

Weather: Dome

Miami couldn't muster anything offensively in a 19-9 loss to Detroit, while the Colts dropped a heartbreaker to the Cowboys 27-23. The Colts showed more life last week, but once again, Daniel Jones made a crucial mistake that cost them.

Coming into this season, we all knew the Dolphins were going to be bad, but we didn't expect the Colts to be as bad as they have been. While the wins aren't there, Miami has been improving week after week, while the Colts seem to be getting worse and worse.

I expect the Fins to run all over the Colts and leave Indy with an upset win.

PREDICTION: DOLPHINS 27, COLTS 24

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CAROLINA PANTHERS @ NEW ORLEANS SAINTS

Sunday, November 15 | 10:00 AM PT | FOX

Line: Saints -2.5 | O/U: 48.5

Weather: Dome

The Panthers lost a tight battle to the Broncos 26-21, while the Saints finally grabbed their first home win of the year, beating the Browns 23-22 in OT.

Both of these teams have been so inconsistent that I really don't know who to take. These divisional matchups are always a coin flip, so this is purely a guess at this point. The Panthers looked a little better on defense against Denver last week and might have pulled off the upset if it weren't for a freak interception.

I also have Tet McMillan on my fantasy team, so screw it, we're going with the Panthers.

PREDICTION: PANTHERS 26, SAINTS 24

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BUFFALO BILLS @ NEW YORK JETS

Sunday, November 15 | 10:00 AM PT | CBS

Line: Bills -8.5 | O/U: 50.5

Weather: 50°F at MetLife Stadium

Like the Vikings, the Bills are on a short week following Monday night. The Jets got absolutely routed by the Chiefs 35-12.

Even on short rest, the Bills are vastly superior to a Jets team that is completely lost right now. Looks like Aaron Glenn will have to wait another week to get that elusive first AFC East divisional win.

PREDICTION: BILLS 31, JETS 17

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SUNDAY LATE WINDOW

SEATTLE SEAHAWKS @ LAS VEGAS RAIDERS

Sunday, November 15 | 1:05 PM PT | CBS

Line: Seahawks -6.5 | O/U: 40.5

Weather: Dome

You already know where my allegiance lies (Allegiant Stadium pun slightly intended), but the numbers back it up. The Seahawks' defense was lights out last week, suffocating the Cardinals 17-3. The Raiders got dismantled by the 49ers 38-17, but they left a lot of points on the board and are a much better team than the score indicates.

Macdonald vs. Kubiak is here. Like most Seahawks games, this one will come down to how much pressure they can generate. Kubiak knows Macdonald wants to make Cousins uncomfortable, so if the Raiders can avoid obvious passing downs, they might have a shot.

Every game for Seattle is seemingly a must-win at this point, so I think that desperation comes out and propels the Hawks to victory.

Update (Wednesday): The Raiders traded Kirk Cousins to Minnesota at Tuesday's deadline, so No. 1 overall pick Fernando Mendoza makes his first career start against Seattle. Justin's pick and best bet were made before the news.

PREDICTION: SEAHAWKS 31, RAIDERS 24

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LOS ANGELES RAMS @ ARIZONA CARDINALS

Sunday, November 15 | 1:05 PM PT | CBS

Line: Rams -9.5 | O/U: 39.5

Weather: Dome

The Rams handled their business against Washington 20-13, while Arizona couldn't get past Seattle's defense, managing just 3 points.

The Rams own this division rivalry, and Arizona's offense looks completely broken. Oh, and by the way, Myles Garrett is back.

Give me the Rams in a blowout.

PREDICTION: RAMS 33, CARDINALS 10

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SAN FRANCISCO 49ERS @ DALLAS COWBOYS

Sunday, November 15 | 1:25 PM PT | FOX

Line: 49ers -3.5 | O/U: 55.5

Weather: Dome

The 49ers continue to be a buzzsaw, crushing the Raiders 38-17. Dallas fought hard to edge out the Colts 27-23.

The total is sky-high at 55.5, but San Francisco's defense will do enough to keep Dallas contained. Dallas might score some points, but I fully expect the Niners to dominate this game.

The Cowboys better be ready for a physical football game. I don't think they are.

PREDICTION: 49ERS 38, COWBOYS 20

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SUNDAY NIGHT

PITTSBURGH STEELERS @ CINCINNATI BENGALS

Sunday, November 15 | 5:20 PM PT | NBC

Line: Bengals -3.5 | O/U: 49.5

Weather: 40°F at Paycor Stadium

An absolute heavyweight clash in the AFC North. The Steelers are coming off a bye week, while the Bengals took care of the Falcons 34-17.

Joe Burrow (aka José Frío) has been able to spread the ball around to all his weapons, making Cincinnati's offense nearly unstoppable with how unpredictable it is. Oh, and they actually have a defense now, too.

These two teams are practically complete opposites. Pittsburgh will want to control this game with its rushing attack and limit the number of possessions Cincy gets. Sexy Dexy was traded to Cincy to clog up running lanes, and I think he'll be able to do enough to give Burrow his opportunities.

WHO DEY!

PREDICTION: BENGALS 27, STEELERS 23

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— Justin Tapp | The Sizzlin CEO